A Psoriasis-Like Skin Eruption. Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Paradoxical hypertension may occur in patients with pheochromocytoma, unless alpha-adrenergic blockade is already instituted. Lancet 1 (1972): 979-82, 26. Applies to propranolol: oral capsule extended release, oral solution, oral tabletOther dosage forms: 1. intravenous solutionAlong with its needed effects, propranolol may cause some unwanted effects. Propranolol can also cause other side effects. Eur J Clin Pharmacol 48 (1995): 29-34. Massa MC, Jason SM, Gradini R, Welykyj S "Lichenoid drug eruption secondary to propranolol." Keep in mind that most of these side effects are likely to occur with long-term Propranolol treatment, such as when treating hypertension or chronic migraine disorder. Lind L, Pollare T, Berne C, Lithell H "Long-term metabolic effects of antihypertensive drugs." Parker WA "Propranolol-induced depression and psychosis." Propranolol Interactions, Risk Factors, and Possible Side Effects . Diarrhea . Pacing Clin Electrophysiol 16 (1993): 496-500, 12. [Ref], Rare (less than 0.1%): Depression (dose dependent), hallucinations, psychoses, mood changes, confusion, memory loss[Ref], Rare (less than 0.1%): Anaphylaxis, contact dermatitis[Ref], Uncommon (0.1% to 1%): Reduction of platelet adhesiveness, thrombocytopenic purpura, nonthrombocytopenic purpura, agranulocytosis, eosinophilia[Ref], Frequency not reported: Stevens - Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, urticaria, purpura, alopecia, skin rashes, SLE-like reactions, Postmarketing reports: Dermatitis psoriasiform[Ref], Postmarketing reports: Enhanced immune system[Ref], Propranolol can enhance the immune system by causing an increase in the number of circulating T cells, increased interleukin-2 (IL-2) secretion, increased expression of IL-2 receptors, and increased lymphocyte production in response to the T cell mitogen Con A. Interestingly, NK (natural killer) cell activity may be decreased during propranolol therapy, although the number of circulating NK cells may remain unchanged. Br J Clin Pharmacol 5 (1978): 415-9, 33. Krauss XH, Schalekamp MA, Kolsters G, et al "Effects of chronic beta-adrenergic blockade on systemic and renal haemodynamic responses to hyperosmotic saline in hypertensive patients." Clin Ther 30 (2008): 1069-80, 52. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. A Significant Type Of Allergic Reaction Called Anaphylaxis. We comply with the HONcode standard for trustworthy health information -, Propranolol Sustained-Release Bead Capsules, blistering, peeling, or loosening of the skin, confusion about identity, place, and time, general feeling of discomfort, illness, or weakness, paleness or cold feeling in the fingertips and toes, peculiar postures or movements, mannerisms, or grimacing, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, reddening of the skin, especially around the ears, seeing, hearing, or feeling things that are not there, skin irritation or rash, including rash that looks like, sores, ulcers, or white spots in the mouth or on the lips, swelling of the eyes, face, fingers, feet, or lower legs, tingling or pain in fingers or toes when exposed to cold, pain or discomfort in the chest, upper stomach, or throat, unusual drowsiness, dullness, or feeling of sluggishness. Clin Pharm 4 (1985): 214-8, 42. Possible side effects. Like all medicines, propranolol can cause side effects, although not everyone gets them. The unwanted effects often improve as your body adjusts to the new medicine, but speak … Valsecchi R, Leighissa P, Piazzolla S, Naldi L, Cainelli T "Occupational contact dermatitis from propranolol." Dr. Mary Margaret ONeill answered. It is possible that your symptoms are related to the medication you are taking. Check with your doctor immediately if any of the following side effects occur while taking propranolol: Some side effects of propranolol may occur that usually do not need medical attention. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Cephalalgia 16 (1996): 328-36, 3. You may report them to the FDA. Serious side effects of Propranolol are very unusual. Contact your doctor if you have rare but serious side effects of Inderal including. Sobel BE "Propranolol and threatened myocardial infarction." [Ref], Very rare (less than 0.01%): Myasthenia gravis like syndrome or exacerbation of myasthenia gravis, Frequency not reported: Myopathy, myotonia[Ref], Very rare (less than 0.01%): Elevated liver function tests[Ref], Rare (less than 0.1%): Dry eyes, visual disturbances[Ref], 1. Patients with a personal or family history of depression had significantly higher scores on depression scales than those without such histories. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings. Koksal AS, Uskudar O, Koklu S, Yuksel O, Beyazit Y, Sahin B "Propranolol-exacerbated mesenteric ischemia in a patient with hyperthyroidism." Do not rinse the dropper. Levinson DF, Acquaviva J "Exacerbation of panic disorder during propranolol therapy." Kasiske BL, Ma JZ, Kalil RS, Louis TA "Effects of antihypertensive therapy on serum lipids." Pollack MH, Rosenbaum JF, Cassem NH "Propranolol and depression revisited: three cases and a review." [Ref], Rare (less than 0.1%): Dyspnea, worsening of reactive airways diseases, bronchospasm in patients with bronchial asthma or a history of asthmatic complaints (sometimes fatal)[Ref]. Am J Emerg Med 13 (1995): 536-7, 41. She took me off the med and my eyes were finally back to normal. Vision may be temporarily blurred or unstable after applying drops. Depression 4. The more common side effects of propranolol can include: slower heart rate; diarrhea; dry … Interestingly, the fall was not related to smoking or to atopic status, suggestive of resting beta-adrenergic bronchodilator activity in nonasthmatic subjects. bloating. Am J Cardiol 18 (1966): 463-72, 23. Lancet 1 (1985): 123-6, 37. Stomach Cramps 6. If stinging persists or becomes bothersome, inform your doctor. chest pain or discomfort. J Cardiovasc Pharmacol 33 (1999): 534-9, 36. 3. Who can and cannot take propranolol. Ann Intern Med 122 (1995): 133-41, 53. Vision blurred is found among people who take Propranolol hydrochloride, especially for people who are female, 40-49 old, have been taking the drug for < 1 month. Medically reviewed by Drugs.com. Aust N Z J Med 25 (1995): 257, 29. van der Woude HJ, Zaagsma J, Postma DS, Winter TH, van Hulst M, Aalbers R "Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers." Sasaki J, Kajiyama G, Kusukawa R, Mori H, Koga S, Takagi R, Tanaka N, Ogawa N, Arakawa K "Effect of bevantolol and propranolol on serum lipids in patients with essential hypertension." Although not all of these side effects may occur, if they do occur they may need medical attention. Applies to propranolol: oral capsule extended release, oral solution, oral tablet. Some side effects may not be reported. Look downward and gently close your eye for 1 to 2 minutes. Side Effects. Since none of the 12 patients with a history of depression were clinically depressed at the start of propranolol therapy and were comparable by age, diagnosis, and propranolol dosage to the other 22 patients, a comparison was made. bloody stools. my eyes feel as though i have been crying for hours and my legs feel weary and weak as thought they are going to go from underneath me. Purpose: A pilot randomized control trial to compare the efficacy and side effects of intralesional and oral propranolol in periorbital and eyelid capillary hemangiomas. Propranolol may also mask the signs of hyperthyroidism by the same mechanism. These side effects are usually mild and short lived. Timoptic. Connect with U.S. certified physicans to be prescribed and recieve propranolol directly to your door. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. One study of 34 hypertensive patients who were taking propranolol found the incidence of depressive symptoms in this population to be 50% to 74% (depending on the criteria used). Circulation 44 (1971): 596-604, 16. 35 years experience Gynecology. Wyeth Laboratories, Philadelphia, PA. 28. The main side effects of propranolol are feeling dizzy or tired, cold hands or feet, difficulties sleeping and nightmares. You can't miss doses. A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome. Contra-indications For all BETA-ADRENOCEPTOR BLOCKERS (SYSTEMIC) See BETA-ADRENOCEPTOR BLOCKERS (SYSTEMIC) Cautions For all BETA-ADRENOCEPTOR BLOCKERS (SYSTEMIC) See BETA-ADRENOCEPTOR BLOCKERS (SYSTEMIC) Interactions. Shortness of Breath Propranolol is a nonselective beta blocker, meaning it affects beta receptors both in … Cunnane JG, Blackwood GW "Psychosis with propanolol: still not recognized?" if propranolol has been prescribed for depression why is one of the side effects actually depression. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. O 0, 17. Common side effects may … The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine. Darga LL, Hakim MJ, Lucas CP, Franklin BA "Comparison of the effects of guanadrel sulfate and propranolol on blood pressure, functional capacity, serum lipoproteins and glucose in systemic hypertension." Propranolol is a prescription medication with the potential for serious side effects, and its usage should not be taken lightly. Parker SD, Curry CS, Hirshman CA "A life-threatening reaction after propranolol administration in the operating room." Limited data have shown a mean fall in maximal midexpiratory flow rate (MMFR) during propranolol therapy relative to placebo in nine of ten patients whose lung function was assessed. Swollen eyelids and conjunctivitis symptoms. This action gives propranolol its antihypertensive (blood pressure lowering) effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Br J Clin Pharmacol 24 (1987): 615-20, 48. difficulty having an orgasm. Gastrointestinal. Imai Y, Watanabe N, Hashimoto J, Nishiyama A, Sakuma H, Sekino H, Omata K, Abe K "Muscle cramps and elevated serum creatine phosphokinase levels induced by beta-adrenoceptor blockers." A 72-year-old retired college professor with no history of affective disorders developed progressive sadness, tearfulness, hopelessness, decreased energy, social withdrawal, anhedonia, insomnia, and decreased memory and concentration within two weeks after beginning propranolol monotherapy for hypertension. Choi KL, Wat MS, Ip TP, Kung AWC, Lam KSL "Phaeochromocytoma associated with myasthenia gravis precipitated by propranolol treatment." Postgrad Med J 63 (1987): 57-8, 44. Dry eye syndrome. Like many other side effects of propranolol, fatigue can often be reduced or avoided by lowering your dosage of the medication. Tell your doctor immediately if any of these unlikely but serious side effects occur: Cutis 48 (1991): 41-3, 49. Holland OB, Kaplan NM "Propranolol in the treatment of hypertension." The likelihood of experiencing any of the side effects will depend on the individual; however, the more serious Propranolol side effects are very unusual, affecting less than one in 10,000 patients. Furthermore, with IVP injection the side effects of systemic route may be minimized as demonstrated with eye drop delivery of propranolol for treatment of retinal neovascularization. Warren DJ, Swainson CP, Wright N "Deterioration in renal function after beta-blockade in patients with chronic renal failure and hypertension." Last updated on Oct 16, 2020. If your child were to start wheezing while on propranolol, the medicine would need to be stopped. Use of a nonselective beta-blocker like propranolol may at least blunt cardiac output in some patients, especially those with preexisting left ventricular systolic dysfunction and during exertion. Clin Sci 44 (1973): 129-34, 19. Side effects of combined medications may include any of the side effects of the drug types they contain. i am having difficulty facing travel and driving will this drug affect my ability to drive. Trouble sleeping. Below is a list of the most common side effects. Dizziness. Hu CH, Miller AC, Peppercorn R, Farber EM "Generalized pustular psoriasis provoked by propranolol." This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. [Ref], Uncommon (0.1% to 1%): Renal insufficiency (related to lowering of systemic blood pressure)[Ref], There are reports of patients who experienced reversible renal insufficiency with no decline in systemic blood pressure, but these patients had preexisting renal disease. The table below contains some of the most common ones associated with propranolol. ).Some health conditions may make you more susceptible to the side-effects of the drug. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings. 16,18. Serious side effects and symptoms. Along with its needed effects, a medicine may cause some unwanted effects. Thiessen BQ, Wallace SM, Blackburn JL, et al "Increased prescribing of antidepressants subsequent to beta-blocker therapy." See the section Side Effects on pages 2 and 3. Call your doctor at once if you have: - slow or uneven heartbeats; - a light-headed feeling, like you might pass out; - wheezing or trouble breathing; Most patients do well on this medicine and do not have problems. Inderide (propranolol hydrochloride and hydrochlorothiazide) is a combination of a beta-blocker and a thiazide diuretic (water pill) used to treat high blood pressure (hypertension).Inderide is available in generic form. 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